She had been getting end-of-life care for inside malignant growth at home
At home had raised millions for disease research.
The host of the BBC's You, Me and the Big C digital broadcast was given a damehood in May
May in acknowledgment of her raising support.
Lady Deborah, a mother of two, was determined to have gut disease in 2016.
Her family portrayed her as "astounding" and an "motivation".
They declared her passing in a post on her Instagram page.
"We are profoundly disheartened to declare the demise of Dame Deborah James"
The most astonishing spouse, little girl, sister, mummy," it said.
She died calmly encompassed by her loved ones.